November 21, 2013 -- 3D Biomatrix, which develops and sells tools for drug discovery research and testing that mimic the human cellular environment, and Cayman Chemical, a supplier of assay kits and biochemical tools, have partnered to develop and supply a novel assay kit for measuring the viability of cells growing in three-dimensional (3D) spheroids.
3D Biomatrix, a leader in three-dimensional cell culture products, is pleased to announce that they have collaborated with Cayman Chemical to develop and supply a new assay kit for measuring the viability of 3D spheroids. The kit, Perfecta3D® Cell Viability Kit, is one of the first viability assays optimized for 3D cell culture.
Researchers have long tested drug compounds and other factors affecting cell growth in two-dimensions (2D), but 2D cell cultures do not accurately represent how cells behave in the body. 3D cell cultures allow researchers to recapitulate these characteristics in vitro, providing a more physiologically-relevant model. 3D Biomatrix’s Perfecta3D Hanging Drop Plates facilitate the consistent and controllable growth of small spherical 3D clusters called spheroids in a well-plate format. Researchers can then test compounds and other factors in a 3D environment that reflects the human body.
The new Perfecta3D 3D Cell Viability Kit provides an easy-to-use format for studying cell proliferation in spheroids formed in the Hanging Drop Plates. The assay, based on the enzymatic cleavage of the tertrazolium salt WST-1 to formazan by cellular mitochondrial dehydrogenases in viable cells, will allow investigators to screen drug candidates involved in cell cycle regulation in a 3D format.
“Our new 3D Cell Viability Assay Kit provides researchers with a solution for 3D cell culture and analysis,” said 3D Biomatrix CEO Laura Schrader. “As Cayman and 3D Biomatrix are leaders in their respective fields, researchers can be confident they are using reagents that have been specifically optimized for their needs in 3D cell culture.”
Jeff Johnson, Vice President of Biochemistry at Cayman Chemical says, “The 3D Biomatrix Perfecta3D Hanging Drop Plate is adding greater versatility to our growing line of cell-based assays. We are excited about the collaboration and the impact it will have on cell biology research.”
3D Biomatrix and Cayman Chemical plan to continue their collaboration with additional 3D cell culture assay kits. More information about the Perfecta3D Cell Viability Kit, including ordering information, can be found on the 3D Biomatrix and Cayman Chemical websites.
About 3D Biomatrix
3D Biomatrix is a life sciences company offering revolutionary solutions for 3D cell cultures. Cells grown with 3D Biomatrix products have been shown to retain a much higher complexity of body response than cells grown in traditional two-dimensional plates and flasks. For more information, visit www.3dbiomatrix.com
About Cayman Chemical
Cayman Chemical Company helps make research possible by supplying scientists worldwide with biochemical tools used to understand cancer, neurochemistry, oxidative injury, endocrinology, atherosclerosis, and other human health challenges. They specialize in assay kits for the measurement of hormones and bio-markers. In addition, Cayman offers a broad range of specialty biochemicals used as research reagents and qualified standards. Cayman performs generic drug development and production in both Ann Arbor, Michigan and Neratovice, Czech Republic. For more information, visit www.caymanchem.com.
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