Taking a major step forward in stem cell biology, researchers at The University of Texas M. D. Anderson Cancer Center have turned muscle progenitor cells — stem cells that are “committed” to becoming muscle tissue — into cells that look and act like neurons (nerve cells).Using an artificial gene they created, the researchers “switched on” a panel of genes that are normally silent in the muscle cells, causing them to morph into cells that show biochemical, physiological, and structural properties of neurons.The researchers say the advance, published in the April 15 issue of Genes and Development, provides evidence that stem cells could be profoundly “flexible” — able to develop into different cell types.
