ST. LOUIS--(BUSINESS WIRE)--Dec. 19, 2005--Tripos, Inc. (Nasdaq:TRPS), a leading provider of drug discovery chemistry and informatics products and services, today announced that it intends to streamline its Discovery Research business and has initiated the 30-day consultation period with employees mandated by U.K. law when job losses are expected in the range of 20 to 99 positions. Any headcount reduction, which will reflect the evaluation and signing of certain pipeline opportunities, is expected to be finalized by the end of January 2006. Tripos Discovery Research Ltd. (TDR) currently has 164 employees, most of which are based at its facility in England.