Tolero Pharmaceuticals, Inc., a clinical-stage company focused on developing novel therapeutics for hematological and oncological diseases, announced today the presentation of preclinical data of TP-1287, an investigational oral cyclin-dependent kinase 9 (CDK9) inhibitor, in castration-sensitive and resistant prostate cancer models and TP-1454, an investigational small-molecule pyruvate kinase M2 isoform (PKM2) activator, in colorectal cancer models
| SALT LAKE CITY, Utah, Oct. 29, 2019 /PRNewswire/ -- Tolero Pharmaceuticals Inc., a clinical-stage company focused on developing novel therapeutics for hematological and oncological diseases, announced today the presentation of preclinical data of TP-1287, an investigational oral cyclin-dependent kinase 9 (CDK9) inhibitor, in castration-sensitive and resistant prostate cancer models and TP-1454, an investigational small-molecule pyruvate kinase M2 isoform (PKM2) activator, in colorectal cancer models. These data were shared at the 2019 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, being held October 26-30, 2019, in Boston, Massachusetts. “We are pleased to present data on our early-stage investigational agents, TP-1287 and TP-1454. These results are a testament to our commitment to develop novel therapeutics and expand the combined oncology portfolio of Tolero and its parent company, Sumitomo Dainippon Pharma,” said David J. Bearss, Ph.D., Chief Executive Officer of Tolero Pharmaceuticals, Inc. “Furthermore, these data improve our understanding of these assets and provide insight into the potential role CDK9 inhibition and PKM2 activation may play in the treatment of prostate and colorectal cancer.” Data from a preclinical prostate cancer model, showed TP-1287 as monotherapy and in combination with venetoclax or docetaxel enhanced tumor growth inhibition. Additionally, TP-1287 combined with docetaxel alone showed tumor growth inhibition. In a separate preclinical colorectal cancer model, TP-1454 in combination with anti-PD1 and anti-CTLA4 therapies showed tumor regression, tumor growth inhibition and an acceptable safety profile. Below are the details for the Tolero presentations:
About TP-1287 About TP-1454 About Tolero Pharmaceuticals, Inc. Tolero Pharmaceuticals is a clinical-stage biopharmaceutical company researching and developing treatments to improve and extend the lives of patients with hematological and oncological diseases. Tolero has a diverse pipeline that targets important biological drivers of blood disorders to treat leukemias, anemia, and solid tumors, as well as targets of drug resistance and transcriptional control. Tolero Pharmaceuticals is based in the United States and is an indirect, wholly-owned subsidiary of Sumitomo Dainippon Pharma Co., Ltd., a pharmaceutical company based in Japan. Tolero works closely with its parent company, Sumitomo Dainippon Pharma, and Boston Biomedical, Inc., also a wholly-owned subsidiary, to achieve a common goal - expediting the discovery, development and commercialization of novel treatment options with the aim of improving patient outcomes. Additional information about the company and its product pipeline can be found at www.toleropharma.com. Tolero Pharmaceuticals Forward-Looking Statements SOURCE Tolero Pharmaceuticals, Inc. |
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