Systemic administration of different ADCs in human tumor xenograft models with established tumors, led to strong antitumor efficacy at doses well below the MTD, ranging from substantial tumor growth inhibition to 100% complete and durable regressions, with varying study parameters such as dose (including single-digit mg/kg), dosing route and dosing schedule (including single-dose). Adverse effects were minimal as indicated by absent or minimal body weight changes in ADC treated groups compared to naked antibody treated groups. For several linker-duocarmycin chemistries a significant therapeutic window was demonstrated.
The results indicate the technology's broad applicability against multiple antigen targets and against a range of cancer indications, including solid tumors. Syntarga has established itself as a company with ADC technology and technological know-how as to the structural requirements for a drug-linker to generate successful ADCs.
Syntarga evaluates its payload chemistries through collaborations with contract research organizations (CROs) and major biopharmaceutical companies. A compilation of in vivo data will be presented at the forthcoming Protein Engineering Summit (April 6 - 10, 2009, Boston, USA) and at the American Association for Cancer Research Annual Meeting (April 18 - 22, 2009, Denver, USA).
About Syntarga BV
Syntarga is a private biopharmaceutical company engaged in the discovery and development of proprietary Antibody-Drug Conjugate technology for the treatment of cancer. The Company's cutting-edge chemistry capabilities and unique know-how have led to the creation of Potent Payload Technology, an antibody empowering technology to generate next generation antibody products for oncology. Syntarga applies its technologies and expertise to generate and commercialize Antibody-Drug Conjugate product candidates based on antibodies of its biopharmaceutical partner.
About Potent Payload Technology
Syntarga Potent Payload Technology comprises extremely potent cell-killing agents that are coupled to suitable linker technologies for attachment to tumor-specific monoclonal antibodies. The targeting properties of monoclonal antibodies combined with Syntarga’s unique and fully synthetic Linker-Drug payload chemistries have yielded a variety of ADC products that have been validated in vivo and were shown to possess a large therapeutic window. The Company’s preclinical stage technologies are based on its duocarmycins, a class of DNA-damaging minor groove binding alkylating agents, which possess a range of unique properties making them highly suitable as ADC warheads.
