Researchers at Rutgers University in Piscataway, N.J., have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a medical journal report. The drugs, called DAPYs, mimic the virus by changing shape, which enables them to interfere with the way HIV attacks the immune system. Tests conducted in conjunction with Johnson & Johnson have shown the drugs to be easily absorbed with minimal side effects. They also can be taken in one pill, in contrast to the drug cocktails currently taken by many AIDS patients. A research team led by Rutgers chemist Eddy Arnold prepublished details of the most promising of the three drugs, known as R278474, last month in the electronic edition of the Journal of Medicinal Chemistry. The research has targeted reverse transcriptase, a submiscroscopic protein composed of two coiled chains of amino acids. It is considered HIV’s key protein.
