SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Reset Therapeutics, Inc., announced today a collaboration with an affiliate of Alkermes plc for the discovery, development and commercialization of novel orexin receptor modulators from Reset’s drug discovery platform. The orexin system is a key modulator of wakefulness, appetite and mood, and its dysregulation is associated with central nervous system (CNS) disorders such as narcolepsy and depression.