Some low birth weight infants have large particles rich in apolipoprotein C-1, a blood protein that could put them at risk for heart disease later in life, according to a national study led by Johns Hopkins Children’s Center researchers. For the study, Peter O. Kwiterovich, Jr., M.D., professor of pediatrics and director of the Lipid Clinic at Johns Hopkins, and colleagues analyzed the umbilical cord blood of 163 infants born at 28 or more weeks of gestational age at Johns Hopkins Hospital between January 3 and September 27, 2000. Nineteen percent of the babies were found to have enriched levels of apolipoprotein C-1 bound up in the high density lipoproteins (HDL) circulating in their blood. These infants were born on average 1.3 pounds less and three weeks earlier than those who had normal HDL levels of the suspect particles. Results are published in the April 20 issue of the Journal of the American Medical Association.
