BASKING RIDGE, N.J., Dec. 17 /PRNewswire/ -- Regado Biosciences, Inc., a privately held company leading the development of antithrombotic therapeutic aptamers with active control agents, today announced the completion of a $40 million Series D financing. The round, led by new investor Edmond de Rothschild Investment Partners, part of The LCF Rothschild Group, was joined by existing investors Domain Associates, Quaker Bioventures, Aurora Funds, Caxton Advantage Life Sciences Fund and other individual investors.
Raphael Wisniewski, Partner at Edmond de Rothschild Investment Partners, said, “Since the introduction of the first antithrombotic therapy, physicians have faced the need to prevent harmful clots while allowing healing clots to form and develop normally. Regado’s exclusive paired aptamer/active control agent technology represents an optimized solution to this dilemma. We and the other investors are convinced of the large unmet medical need for this technology, which represents a novel approach to the practice of personalized medicine in the cardiovascular acute and sub-acute care market.”
ABOUT REGADO BIOSCIENCES
Regado Biosciences is pioneering a new therapeutic technology with the creation and development of two-component drug systems. Each system comprises a nuclease-stabilized RNA aptamer that can be controlled directly by its specific and complementary oligonucleotide active control agent. This technology is being applied to injectable antithrombotics, including anticoagulants and antiplatelet agents, a multi-billion dollar market in need of therapeutics with improved safety profiles and a greater degree of therapeutic control. Regado’s technology is designed to give physicians the ability to actively and directly control each system’s therapeutic effect providing a safe and unique approach to personalized medicine. More information can be found at www.regadobio.com.
ABOUT APTAMERS
RB006 is a member of a class of compounds called aptamers. Aptamers are single stranded oligonucleotides that adopt a specific conformation enabling direct, specific inhibition of the targeted protein. A key unique feature of aptamers derives from the fact that they are formed from nucleic acids. As such, their pharmacologic activity can be controlled by a matched, complementary oligonucleotide active control agent (RB007; the Watson-Crick base pair complement of a fraction of the agent to be controlled), which can bind to the aptamer, removing it from its target and reversing it biologic effects.
ABOUT DOMAIN ASSOCIATES
Founded in 1985, Domain Associates, L.L.C. is a venture capital firm with an exclusive focus on life sciences. With $2.5 billion of capital under management, Domain has offices in Princeton, NJ and San Diego, CA. For more information, please visit www.domainvc.com.
ABOUT AURORA FUNDS
The Aurora Funds is a venture capital firm that provides capital, connections and strategic guidance to entrepreneurs with early-stage healthcare and information technology companies. Founded in 1994, Aurora manages over $234 million in five venture funds. The firm’s three investment professionals have over 45 years of combined venture capital investing and operational experience. For more information, see www.aurorafunds.com.
Regado Biosciences, Inc.
