Opioid antagonists are drugs that are used to block the effects of opioids. Opioid antagonists block one or more of opioid receptors in either the central or peripheral nervous system. Thus, they block the overall activity of opioid.
Opioid Antagonist: Introduction
- Opioid antagonists are drugs that are used to block the effects of opioids. Opioid antagonists block one or more of opioid receptors in either the central or peripheral nervous system. Thus, they block the overall activity of opioid.
- Opioid antagonists hold promising potential to reverse the life threatening toxic effects of overdosage of opioids. These are widely used in palliative care for the treatment of opioid-induced constipation.
- Naloxone, naltrexone, and Nalgene are the commonly used opioid antagonists across the globe
- Opioid antagonist is considered an ideal medication to deal with opioid medication crisis in most of the developed countries. It is a proven medication that saves the life of a patient addicted to opioids.
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Opioid Antagonist Market: Key Drivers
- Emergence of the opioid epidemic is one of the prominent factors driving the global opioid antagonists market. The opioid epidemic refers to rise in number of deaths and hospitalization due to overdosage of opioids (including prescriptions, illicit drugs, and analogs). For instance, according to the U.S.-based National Institute on Drug Abuse, every day around 128 people died due to overdosage of opioids in the country in 2018. Addiction to and misuse of opioids including pain-reliever opioids, heroin, and synthetic opioids lead to significant crisis on social, economic, and public health.
- Opioids are commonly prescribed for underlying causes of chronic pain such as cancer, trauma and injury cases, post-operative pain, and arthritis disorders. This is also estimated to indirectly drive the market during the forecast period.
- Large number of drugs in clinical trials, new product development and commercialization, and regulatory guidelines to minimize the opioid crisis are factors projected to augment the market during the forecast period
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Mu Opioid Receptor Segment to Dominate Global Market
- In terms of opioid receptor, the global opioid antagonist market can be classified into mu receptor, kappa receptor, delta receptor, and others. The mu receptor segment is projected to dominate the global market during the forecast period.
- Opioid receptors play a crucial role in expressing pain transmission and signal pathway modulation including neurotransmission in limbs, midbrain, spinal cord, and thalamus
- Majority of opioid receptors belong to the mu receptor class and have minimum side-effects compared to other opioid receptors
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Centrally Acting Opioid Receptors Mechanism of Action Segment to be Highly Attractive
- In terms of mechanism of action, the global market can be segmented into centrally acting opioid receptors and peripherally acting opioid receptors. The centrally acting opioid receptor segment is estimated to create lucrative opportunities during the forecast period.
- Naloxone is a commonly used centrally acting opioid receptor. It has the highest affinity for the mu receptor.
Parenteral Route of Administration Segment Projected to Lead Global Market
- In terms of route of administration, the global market can be divided into oral route, parenteral route, nasal route, and transdermal patch. The parenteral route segment is estimated to dominate the global market during the forecast period.
- Parenteral route of administration is commonly used to maintain long-lasting effect of opioid antagonist. It is widely used in patients with severe adverse effects of opioids.
Pain Application Segment to Offer Lucrative Opportunities in Global Market
- In terms of application, the global market can be segregated into pain, addiction treatment, opioid induced constipation, and others. The pain segment is projected to offer lucrative opportunities to new players planning to enter the market.
- High prevalence of chronic pain due to various medical conditions and trauma cases across the globe is estimated to fuel the demand for opioid antagonists in the near future
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Key Players Operating in Global Opioid Antagonist Market
- The global opioid antagonist market is fragmented, with large number of global players holding majority market share. Key players operating in the global opioid antagonist market include:
- Purdue Pharma L.P.
- Indivior UK Limited.
- Reckitt Benckiser Pharmaceuticals Inc.
- Allergan plc.
- Teva Pharmaceutical Industries Ltd.
- Mylan N.V.
- ADAPT Pharma, Inc.
- kaleo, Inc.
- Mallinckrodt Pharmaceuticals.
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