Malaria is the world’s most frequent parasitic disease, affecting more than 100 countries in the tropical zones, mostly in Africa, and 40% of the world population, with more than a million deaths per year. As a consequence countries affected by malaria also tend to be economically disadvantaged. The development of a vaccine constitutes a major scientific and health challenge. Research conducted at the Biochemistry Department of the University of Lausanne, Switzerland, has established a novel approach for the rapid discovery and development of vaccine candidates.