New Research Shows Progression to Esophageal Cancer as Detected by WATS3D

This study titled “Progression of Barrett’s esophagus, crypt dysplasia, and low-grade dysplasia diagnosed by wide-area transepithelial sampling with 3-dimensional computer-assisted analysis: a retrospective analysis,” was authored by Nicholas J. Shaheen, MD, MPH, Michael S. Smith, MD, MBA and Robert D. Odze, MD, FRCPc. It evaluated 4,545 BE patients and illustrated that patients with baseline non-dysplastic BE progressed to either high-grade dysplasia or cancer at a rate of 0.08%/patient-year (95% confidence intervals (CI), 0.02%-0.14%). Progression of BE patients with baseline crypt dysplasia was significantly higher, at 1.42%/patient-year (95% CI, 0%-3.01%) and progression from baseline low-grade dysplasia was the highest, at 5.79%/patient-year (95% CI, 1.02%-10.55%).

“This publication shows for the first time that WATS^3D helps to detect clinically-significant pathologic lesions and provides insight into the progression rates of BE and dysplasia to cancer,” said Bill Huffnagle, CEO of CDx Diagnostics. “By improving detection of BE and dysplasia, WATS^3D can help clinicians treat their patients and prevent cancer development.”

WATS^3D is a diagnostic platform developed by CDx Diagnostics for the detection of BE and its associated neoplastic conditions. This platform helps clinicians overcome the well-known limitations associated with traditional upper endoscopic methods of screening and surveillance for BE. WATS^3D utilizes advanced tissue sampling, 3D imaging technology and an Artificial Intelligence neural network to more accurately and reliably identify BE and dysplasia. WATS^3D diagnoses are then made by a highly specialized team of WATS^3D trained pathologists.

In other multicenter clinical studies, WATS^3D has been found to significantly increase the detection rate of BE and dysplasia, both of which are treatable precursors to esophageal cancer, one of the fastest growing and most fatal cancers in the United States.

WATS^3D is included in the American Society for Gastrointestinal Endoscopy (ASGE) Guideline for the screening and surveillance of BE. It is also recognized by several other GI societies for the detection of BE and dysplasia, including the American Foregut Society (AFS) and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES).

About CDx Diagnostics

CDx Diagnostics’ mission of Empowering Physicians with Innovative Technology to Prevent Esophageal Cancer, One Patient at a Time is accomplished through a proprietary diagnostic platform. This combination of technology synthesizes computer imaging, artificial intelligence, molecular biology and three-dimensional cytopathology to detect precancerous changes earlier and more reliably than prior methods. CDx tests require only a few minutes of practice time, are highly cost effective, widely reimbursed, and address a recognized critical gap in the current diagnostic standard of care. Routine clinical use of CDx testing has detected thousands of cancers and precancerous conditions that otherwise would have been missed in time for effective treatment. CDx Diagnostics is a Galen Partners portfolio company. To learn more, visit www.cdxdiagnostics.com.

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