NORTH BRUNSWICK, N.J.--(BUSINESS WIRE)--The U.S. Patent and Trademark Office (USPTO) issued today patent 7,488,487 “Methods of Inducing Immune Response Through the Administration of Auxotrophic Attenuated DAL/DAT Double Mutant Listeria Strains,” by Dr. Fred Frankel, et al, which is assigned to the Trustees of the University of Pennsylvania and licensed to Advaxis, Incorporated (OTCBB: ADXS).