Von Economo neurons (VENs) are uniquely shaped brain cells that seem to have evolved in a select group of socially complex species: great apes, humans, and, as reported last month, whales. Across species, VENs are localized to frontal brain regions associated with cognition, emotion and social behavior. Frontotemporal dementia (FTD), a common neurodegenerative condition, is characterized by early breakdown in social and emotional awareness and is accompanied by atrophy and dysfunction in the brain areas where VENs are located. A new study published in the December 2006 issue of Annals of Neurology (http://www.interscience.wiley.com/journal/ana), the official journal of the American Neurological Association, examined brain tissue acquired at autopsy and found that VENs were devastated in FTD.>>> Discuss This Story