Kyowa Kirin, Inc., an affiliate of Kyowa Kirin Co., Ltd. (Kyowa Kirin, TSE: 4151), a global specialty pharmaceutical company, will share results from a retrospective study evaluating real-world utilization of istradefylline along with other Parkinson’s disease (PD) medications among patients with PD.
BEDMINSTER, N.J., May 12, 2023 /PRNewswire/ -- Kyowa Kirin, Inc., an affiliate of Kyowa Kirin Co., Ltd. (Kyowa Kirin, TSE: 4151), a global specialty pharmaceutical company, will share results from a retrospective study evaluating real-world utilization of istradefylline along with other Parkinson’s disease (PD) medications among patients with PD.1 These findings will be presented on Sunday, May 14 from 12:15 - 1:15 PM CDT at the International Association of Parkinsonism and Related Disorders (IAPRD) conference in Chicago, Illinois. As PD progresses, approximately 50% of patients will experience off time, which is a return of Parkinson’s disease symptoms between doses of levodopa within 5 years of initiating levodopa treatment. 2,3,4NOURIANZ® (istradefylline) is prescription medication indicated as adjunctive treatment to levodopa/carbidopa in adult patients with PD experiencing “off” episodes. Patients with Parkinson’s disease are often on multiple medications to manage their PD symptoms or “off” episodes.5 This underscores the need to evaluate polypharmacy medication use in order to contribute to medical understanding of treatment regimens and appropriate patient management. About Study Design About Parkinson’s Disease About Nourianz® (istradefylline) Important Safety Information Warnings and Precautions Dyskinesia: istradefylline in combination with levodopa may cause dyskinesia or exacerbate pre-existing dyskinesia. In clinical trials, 1% of patients treated with either istradefylline 20 mg or 40 mg discontinued treatment because of dyskinesia, compared to 0% for placebo. Hallucinations / Psychotic Behavior: Because of the potential risk of exacerbating psychosis, patients with a major psychotic disorder should not be treated with istradefylline. Consider dosage reduction or discontinuation if a patient develops hallucinations or psychotic behaviors while taking istradefylline. Impulse Control / Compulsive Behaviors: Patients treated with istradefylline and one or more medication(s) for the treatment of Parkinson’s disease (including levodopa) may experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge or compulsive eating, and/or other intense urges, and the inability to control these urges. In clinical trials, 1 patient treated with istradefylline 40 mg was reported to have impulse control disorder, compared to no patient on istradefylline 20 mg or placebo. Drug Interactions The maximum recommended dosage in patients taking strong CYP3A4 inhibitors is 20 mg once daily. Avoid use of istradefylline with strong CYP3A4 inducers. Specific Populations Pregnancy: Based on animal data, may cause fetal harm. Hepatic impairment: The maximum recommended dosage of istradefylline in patients with moderate hepatic impairment is 20 mg once daily. Avoid use in patients with severe hepatic impairment. Adverse Reactions The most common adverse reactions with an incidence ≥5% and occurring more frequently than with placebo were dyskinesia (15%, 17%, and 8%), dizziness (3%, 6%, and 4%), constipation (5%, 6%, and 3%), nausea (4%, 6%, and 5%), hallucination (2%, 6%, and 3%), and insomnia (1%, 6%, and 4%) for istradefylline 20 mg, 40 mg, and placebo, respectively. You are encouraged to report suspected adverse reactions to Kyowa Kirin, Inc. at 1-844-768-3544 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Please click to see full Prescribing Information for Nourianz. About Kyowa Kirin You can learn more about the Kyowa Kirin North America at: https://kkna.kyowakirin.com/. Nourianz® is a trademark of Kyowa Kirin Co., Ltd. REFERENCES
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