International Penta Has Not Fully Disclosed The Nature Of Its Helix Biopharma Share Position

AURORA, ON, Jan. 16 /PRNewswire-FirstCall/ - Helix BioPharma Corp.

Helix’s attorneys in Europe were informed yesterday that all the Helix shares owned by International Penta are in the process of being sold by an international bank under a judicial order in Switzerland. The dissident proxy circular discloses that International Penta holds 2,035,698 Helix shares.

Blocks of International Penta’s holdings have been sold into the marketplace over approximately the past 2 years, in order to make up for a debt International Penta owes. Furthermore, the bank is ordered to sell the balance of International Penta’s holdings.

In addition, Mr. Janssen, as disclosed in the dissident proxy circular owns no Helix common shares personally.

------------------------------------------------------------------------- VOTE YOUR YELLOW HELIX PROXY NOW DO NOT VOTE A BLUE PROXY ----------- IF YOU HAVE ALREADY VOTED A BLUE PROXY, YOU CAN REVOKE IT BY SENDING IN A YELLOW HELIX PROXY NOW --- -------------------------------------------------------------------------

Also see Helix’s response to the dissident proxy circular dated January 10, 2007, filed at www.sedar.com and at www.helixbiopharma.com.

Helix recommends that all shareholders vote only their YELLOW Helix proxy FOR the private placement and FOR the election of Jerome F. McElroy, Donald H. Segal, Kenneth A. Cawkell, Conor Gunne, Richard Rossman, Jack Kay and Gordon M. Lickrish.

MAKE YOUR VOTE COUNT. PLEASE SIGN, DATE AND RETURN YOUR YELLOW PROXY BY JANUARY 19, 2007 AT 10:00 AM TORONTO TIME (EST) FOR YOUR VOTE TO COUNT.

A copy of Helix BioPharma’s current Annual Report and Management Information Circular for the January 23, 2007 meeting can be found on SEDAR at www.sedar.com, and at Helix’s website at www.helixbiopharma.com. Requests for a hard copy of the Annual Report or Management Information Circular can also be made to Georgeson.

Georgeson North American Toll Free Number: 1-866-288-9745 Outside North America Collect: +1-416-642-7018 (x) Toll Free - European: 00800 1020 1010 European Collect: +44 (0) 117 378 5993 (x) Australia; Austria; Belgium; Denmark; Finland; France; Germany; Hong Kong; Ireland; Israel; Italy; Netherlands; New Zealand; Norway; Spain; Sweden; Switzerland; Thailand; United Kingdom Please visit our website for regular updates at www.helixbiopharma.com

Helix BioPharma Corp.

CONTACT: For more information and assistance in completing your YELLOWHelix proxy, please call Georgeson, Helix’s proxy solicitor: North Americantoll free number, 1-866-288-9745, European(x) toll free number,00800-1020-1010. Collect calls outside North America can be made at (416)642-7018 or +44(0)117-378-5993.