Smoking increases the risk of advanced kidney cancer, researchers report. In a new study, a team from Duke University Medical Center reviewed the cases of 845 patients who had had surgery for kidney cancer -- or renal cell carcinoma -- between 2000 and 2009. They found that current and former smokers were 1.5 to 1.6 times more likely to have advanced cancer than nonsmokers. Heavy smoking (smoking for a longer period of time and smoking more) was associated with advanced renal cell carcinoma. Kicking the habit reduced the risk of advanced disease by 9 percent for every 10 years that a former smoker was smoke-free, the investigators found.