SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--The Fluidigm TOPAZ® system has played a major role in the structure determination of Anti-Silencing Function 1 (Asf1) with histones H3/H4. Asf1 is a highly conserved chaperone of histones H3/H4 that assembles or disassembles chromatin during transcription, replication, and repair. Understanding the interaction between these proteins can help scientists learn to control and correct the chromosomal defects that can lead to cancer and genetic disease. The research, published in the November 3, 2006 issue of Cell, was conducted at the University of Colorado at Denver and Health Sciences Center. The paper, entitled “Structural Basis for the Histone Chaperone Activity of Asf1,” is representative of the ongoing success research groups achieve using the TOPAZ system.
