Investigators at St. Jude Children’s Research Hospital had a molecule? eye view of the human cell? DNA repair kit as it assembled on a double-strand break to link together the broken ends. Double-strand breaks are ruptures that cut completely across the twisted, ladder-like structure of DNA, breaking it into two pieces. Using a technique developed specifically for this project, the St. Jude researchers could determine when repair proteins arrived at or around the DNA break and evaluate its repair?ven when particular proteins shifted away from the break to make room for others. A report on this work appears in the May 7 online issue of “Nature Cell Biology.” >>> Discuss This Story
