To assist researchers further, scientists from Creative Biolabs successfully updated its Native Shark Antibody Discovery Service recently.
To assist researchers further, scientists from Creative Biolabs successfully updated its Native™ Shark Antibody Discovery Service recently.
Sharks, along with other members in Chondrichthyes, are currently recognized as the most evolutionarily ancient animals that rely on antibodies as part of their adaptive immune system. Interestingly, apart from the expected IgM and IgW, cartilaginous fishes also produce a type of ancestral antibody referred to immunoglobulin new antigen receptor (IgNAR). IgNAR is quite unconventional antibody composed of only a homodimeric heavy chain which contains one variable and five constant domains for each chain. Because of the distinct structure between shark and human antibody domains, the extremely high stability of IgNAR has been presented. In addition, VNAR is around 10 times smaller than standard antibodies and is able to continue to function and exist within very extreme conditions. These properties allow IgNAR to play a potential role in pharmaceutical application. They can easily get into certain spots that regular size antibodies cannot, such as small gaps and nooks in cancer cells. Moreover, the variable domain of IgNAR can also be developed as single domain antibodies.
With years of research and development experience in antibody discovery, scientists of Creative Biolabs have developed the Native™ Antibody Discovery Platform to generate monoclonal antibody with native and in vivo characteristics.
This proprietary platform takes advantage of the antigen-specific B lymphocytes cytometry technology, and can ideally generate large scale of candidate shark antibody in one step. Moreover, these shark antibodies are all composed of native paired heavy-chains and light-chains (for IgM and IgW) or just heavy-chains (for IgNAR), and have already gone through the in vivo affinity maturation. Thus, its Native™ shark monoclonal antibody will possess higher specificity and affinity than those produced by other techniques and will be intrinsically more appropriate for the development of single domain antibody or other research objectives.
About Creative Biolabs
Creative Biolabs has been a long-term expert in the field of antibody development and manufacturing. Our scientists take pride in having earned great reputation from our global clients by satisfactorily completed thousands of relevant projects in the past decade.
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