CAMBRIDGE, Mass.--(BUSINESS WIRE)--May 10, 2006--CombinatoRx, Incorporated (NASDAQ: CRXX - News) today announced that on May 5, 2006 it appointed Barbara Deptula, an independent director, to serve on the Audit Committee to replace Jacob Goldfield. On May 5, 2006, CombinatoRx received notice from NASDAQ that the Audit Committee of the Company’s Board of Directors did not consist of three independent directors, as required by the listing requirements of NASD Marketplace Rule 4350(d)(2) and also received written confirmation that with the appointment of Ms. Deptula, the rule had been satisfied, and the matter is closed.