CAMBRIDGE, Mass.--(BUSINESS WIRE)--AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced that the United States Patent and Trademark Office granted to AVEO U.S. Patent No. 7,544,476. This patent covers the use of the expression level of a single gene, HeyL, as a predictive biomarker to identify human tumors that are likely to respond to treatment with inhibitors of the Notch pathway, thus adding to the intellectual property surrounding AVEO’s proprietary and translational biology platform.