BNET -- AstraZeneca (AZN) has allegedly known since 2006 that Nexium, its top-selling drug, puts users at an increased risk of bone fractures but failed to warn patients of that until 2010.Millions of people use Nexium, its sister drug Prilosec, or other generic proton pump inhibitors, to control heartburn and acid reflux. But how many of them also know that the risk of hip fractures in the over-50s rises alarmingly if you take the drug on a daily basis?