People with intermittent explosive disorder — a psychiatric illness characterized by impulsivity, hostility and recurrent aggressive outbursts — have elevated levels of two markers of systemic inflammation in their blood, according to a study involving nearly 200 subjects. The paper, published in the December 18, 2013, issue of JAMA Psychiatry, is the first carefully controlled study to document a direct relationship between inflammatory markers and recurrent, problematic, impulsive aggression in people diagnosed with intermittent explosive disorder, but not in people in good mental health or those with other psychiatric disorders.
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