Tosoh Bioscience LLC Announces New High Capacity TOYOPEARL® Protein A Resin

Published: Oct 31, 2013

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Thursday, October 31, 2013 -- biomolecules, announced today the introduction of a new Protein A chromatography resin designed for the purification of monoclonal antibodies (mAbs). This resin is now available for sale in the Americas from Tosoh Bioscience.

TOYOPEARL AF-rProtein A HC-650F resin exhibits dynamic binding capacities of greater than 70 g/L at residence times of 5 minutes and greater than 50 g/L at residence times of 2 minutes with feed stock titers from 1.0 g/L to 10.0 g/L.

Protein A resins constitute a substantial cost in state-of-the-art mAb purification processes. Factors such as operating cycles, capacity, and mAb titer can have an impact on total costs associated with mAb purification. The high capacity of the new TOYOPEARL AF-rProtein A HC-650F resin increases product throughput, reduces operating costs and increases manufacturing productivity.

According to Chris Manzari, Marketing Manager for process chromatography media at Tosoh Bioscience LLC, “we are very pleased to announce that TOYOPEARL AF-rProtein A HC-650F is available for order today to chromatographers in need of the capacity and performance this resin has to offer”.


Tosoh Bioscience LLC provides liquid chromatography products to laboratories and manufacturing plants in the Americas. While the majority of our customers work in biotechnology and pharmaceutical companies, our HPLC columns and systems are essential tools for sample analysis in most industries. In the field of biotechnology, our preparative chromatography resins play a critical role in the purification of proteins and nucleic acids for medical purposes.

The company is a subsidiary of Tosoh Corporation in Japan, the parent of the Tosoh Group, which comprises 141 companies worldwide and a multiethnic workforce of over 10,000 people and generates sales of ¥827 billion (US $8.3 billion) annually.

For more information, please contact

R. Christopher Manzari

Marketing Manager for Process Chromatography

Tosoh Bioscience LLC


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