RefleXion Announces 14 Medical Physics Investigations at 2022 AAPM Annual Meeting

July 11, 2022 11:06 UTC


Oral presentation evaluating feasibility of BgRT using long-lived immune PET tracer awarded Best in Physics


HAYWARD, Calif.--(BUSINESS WIRE)-- RefleXion Medical, a therapeutic oncology company pioneering the use of biology-guided radiotherapy (BgRT)* for all stages of cancer, today announced that researchers will present new data from 14 medical physics investigations validating the efficacy and feasibility of the RefleXion® X1 radiotherapy platform with and without BgRT at the 2022 American Association of Physicists in Medicine (AAPM) Annual Meeting in Washington, D.C., July 10-14.

Two of the 14 abstracts are oral presentations, one of which was selected as “Best in Physics,” a distinction granted to only 15 abstracts by the AAPM. The company is showcasing the X1 radiotherapy platform and future BgRT capabilities in booth #5093.

RefleXion is also hosting an industry lunch symposium during the AAPM annual meeting at 12:45 pm EDT today. Titled “Preparing for Biology-guided Radiotherapy in the Clinic,” the symposium features a presentation on BgRT and advantages for eliminating challenges with motion management by Murat Surucu, Ph.D., as well as a presentation on BgRT commissioning and workflow by Nataliya Kovalchuk, Ph.D., based on their facility’s experience participating in RefleXion’s Investigational Device Exemption (IDE) clinical study.

“We are extremely encouraged by the growing body of scientific evidence validating the RefleXion X1 platform, the future potential of BgRT, and its impact on workflow and treatment planning,” said Sean Shirvani, M.D., chief medical officer of RefleXion. “To have 14 medical physics investigations presented at AAPM, including an oral presentation that earned the distinction ‘Best in Physics,’ further underscores our commitment to achieving and surpassing industry standards of quality radiotherapy treatments for patients.”

The following two oral presentations and two poster presentations highlight some of the new research being shared regarding the use of BgRT for treatment planning for various anatomic sites, time savings, and simplification in workflow:

Oral Presentations:

  • “Evaluation of 89Zr immune-PET for Biology Guided Radiation Therapy,” selected “Best in Physics,” and presented by Guillem Pratx, Ph.D., Thursday, July 14, from 7:30 am – 8:30 am EDT. This study investigated whether a long-lived PET isotope tagged with antibody (immune-PET) could simplify the BgRT workflow by reducing the multiple tracer injections while improving tumor-specific uptake and guidance.

Poster Presentations:

About RefleXion Medical

RefleXion is a privately-held company developing the first biology-guided radiotherapy system, a significant change in strategy from single tumor therapy to the ability to one day treat multiple tumors in cancers that have metastasized. Currently, the RefleXion X1 machine is cleared for the delivery of stereotactic body radiotherapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated radiotherapy (IMRT). The company is also developing BgRT, which incorporates positron-emission tomography (PET) imaging data to enable tumors to continuously signal their location. The BgRT technology will synchronize these data with the linear accelerator to direct radiotherapy to tumors with subsecond latency.

*The RefleXion® X1 is cleared for SBRT/SRS/IMRT. BgRT is pending regulatory review and is not commercially available.


Amy Cook


Source: RefleXion Medical

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