Notch Therapeutics Appoints David Main as President and Chief Executive Officer to Advance the Company's Novel Gene-Edited, iPSC-Derived Immune Cell Therapeutics
TORONTO, July 20, 2020 /PRNewswire/ -- Notch Therapeutics Inc., a biotechnology company creating universally compatible, off-the-shelf T cell therapies for cancer and immune disorders from renewable stem cell sources, is pleased to announce the appointment of David Main as President and Chief Executive Officer.
Notch is applying its scalable Engineered Thymic Niche (ETN) technology platform to develop homogeneous and universally compatible, stem cell-derived T cell therapies. To date, Notch has assembled a world-class scientific team and built a fully integrated, tightly controlled platform for generating and editing immune cells from clonal stem cells to enable development of a broad range of T cell therapeutics. Notch has also entered into a partnership with Allogene Therapeutics (NASDAQ: ALLO) to apply Notch's proprietary ETN platform to develop CAR-targeted, induced pluripotent stem cell (iPSC)-derived, off-the-shelf T cell or natural killer (NK) cell therapies for hematologic cancer indications.
"We have a clear goal at Notch: To create universally compatible, safe, and effective immunotherapies with the capability to treat thousands of patients from a single manufacturing run," said David Main. "The company has an internationally recognized team, a groundbreaking technology positioned to redefine and expand the clinical and commercial potential of cell therapy, and has already attracted a leading corporate partner. This is an exciting time to join and lead the company, which is now strongly positioned to advance our own pipeline of products as we also pursue additional partnering opportunities."
"We have spent the past year building a leading company developing next-generation, off-the-shelf immunotherapies driven by outstanding science and focused execution," said Ulrik Nielsen, Ph.D., Chairman of Notch. "David provides Notch with a proven industry leader and strategic thinker who has extensive experience driving and financing biotech innovation from early-stage research through commercial readiness. We are excited to bring in such outstanding leadership that is ideally suited to lead the company as it continues to advance its new class of off-the-shelf T cell therapy products."
Mr. Main is a highly experienced biopharmaceutical executive who brings to Notch more than 30 years of industry leadership experience with a strong track record of value creation and company growth. Most recently, as co-founder, Chairman, and CEO of Aquinox Pharmaceuticals, Mr. Main oversaw the advancement of the company's lead product from target validation through Phase 3 clinical trials. He also led the transition of Aquinox from a private to a NASDAQ-listed public company with approximately $300 million raised in equity capital and then completed the successful merger of Aquinox with Neoleukin Therapeutics. Prior to his leadership of Aquinox, Mr. Main served as President and CEO of INEX Pharmaceuticals and as a Vice President of QLT.
About Notch Therapeutics (www.notchtx.com)
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SOURCE Notch Therapeutics
Company Codes: NASDAQ-NMS:ALLO