Milestone Scientific Announces Publication Of Favorable Article On Potential Use Of CompuFlo(R) For Epidurals

LIVINGSTON, N.J., Oct. 27 /PRNewswire-FirstCall/ -- Milestone Scientific Inc. , which develops, manufactures and markets computer controlled local anesthetic delivery systems, today announced that a favorable article on the potential use of Milestone's CompuFlo device for the administration of epidural anesthesia was published in the October issue of Anesthesiology News, the independent monthly newspaper for anesthesiologists. The article provides further validation of the potential efficacy of the use of CompuFlo for Epidural Blocks, injections that are regularly administered for a variety of medical procedures including childbirth, back pain management and surgery to the lower extremities.

The Anesthesiology News article reports on a presentation by Oscar Ghelber, MD, Assistant Professor of Anesthesiology, University of Texas Health Science Center, Houston, to the 2005 Annual Meeting of the International Anesthesia Research Society. Dr. Ghelber noted that existing epidural techniques use subjective feedback to identify the epidural space, while the CompuFlo technology provides precise and objective feedback and also allows anesthesiologists to use both hands to advance and direct the needle, thereby making it easier to perform this task. Dr. Ghelber further advised the meeting that the CompuFlo accurately identified the epidural space in 100% of the cases tested in his pilot study. Dr. Ghelber opined that an objective identification of the epidural space "could potentially decrease the incidence of complications, increase the success rate of the procedure and enhance patient safety."

About Milestone Scientific Inc.

Milestone Scientific is the developer, manufacturer and marketer of CompuMed(R) and CompuDent(R) computer controlled local anesthetic delivery systems. These systems comprise a microprocessor controlled drive unit as well as The Wand(R) handpiece, a single patient use product that is held in a pen-like manner for injections. The Company also sells the SafetyWand(R), which incorporates engineered sharps injury protection features to aid in the prevention of accidental needlesticks. Milestone has also developed proprietary consumer (Ionic White) and professional (Cool Blue) teeth whitening systems that were introduced to the market earlier this year.

In 2001, Milestone Scientific received broad United States patent protection on an enabling technology for computer controlled, pressure sensitive infusion, perfusion, suffusion and aspiration, which provides real time displays of pressures, fluid densities and flow rates, that advances the delivery and removal of a wide array of fluids. Development of this CompuFlo technology is currently underway.

The Company is headquartered in Livingston, New Jersey, and its common stock trades on the American Stock Exchange under the symbol "MS".

This press release contains forward-looking statements regarding the timing and financial impact of the Milestone's ability to implement its business plan, expected revenues and future success. These statements involve a number of risks and uncertainties and are based on assumptions involving judgments with respect to future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond Milestone's control. Some of the important factors that could cause actual results to differ materially from those indicated by the forward-looking statements are general economic conditions, failure to achieve expected revenue growth, changes in our operating expenses, adverse patent rulings, FDA or legal developments, competitive pressures, changes in customer and market requirements and standards, and the risk factors detailed from time to time in Milestone's periodic filings with the Securities and Exchange Commission, including without limitation, Milestone's Annual Report on Form 10-KSB for the year ended December 31, 2003. The forward-looking statements in this press release are based upon management's reasonable belief as of the date hereof. Milestone undertakes no obligation to revise or update publicly any forward- looking statements for any reason.

CONTACT Leonard Osser, CEO Tom Ronca, COO Milestone Scientific Inc (973) 535-2717; (973) 535-2829 (Fax) Web site: www.milesci.com

Milestone Scientific Inc.

CONTACT: Leonard Osser, CEO, or Tom Ronca, COO, both of MilestoneScientific Inc, +1-973-535-2717, or fax, +1-973-535-2829

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