Complete Genomics, Inc. Release: Whole Genome Sequencing in Type 2 Diabetes Genetic Study
Published: May 09, 2012
“We are optimistic that this multigenerational, whole genome sequencing study will help us to identify some of the rare variants involved in type 2 diabetes that have eluded us to date,” said Dr. John Blangero, a geneticist at the Texas Biomedical Research Institute in San Antonio and one of the researchers. “Our aim is to identify genetic variants that play a role in type 2 diabetes risk or influence variability in diabetes-related traits, such as blood glucose levels and body mass index.”
The study, carried out as part of the T2D-GENES (Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples) consortium, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health.
Researchers at the Texas Biomedical Research Institute and their collaborators have been collecting healthcare data from approximately 2,500 members of 85 Mexican-American families since 1991. The 600 individuals selected for this whole genome sequencing study were previously genotyped in an earlier genome-wide association study and are members of several of the largest families with increased prevalence of diabetes. While the earlier study targeted common genetic variants associated with diabetes, the whole genome sequencing study will now facilitate the search for less common and rare variants associated with diabetes. This new study has the potential to reveal subtypes of type 2 diabetes and identify novel therapeutic targets.
“We have already begun analyzing the whole genome sequencing data that we received from Complete Genomics. The genomes were sequenced to an average of >50x coverage and we are very pleased with the high quality of the data,” said Dr. Blangero. “We will use the sequencing data to fill in the gaps in our genotyping data.”
Mexican-Americans are almost twice as likely as non-Hispanic whites to be diagnosed with diabetes, according to the U.S. Department of Health and Human Services. This population also has higher rates of end-stage renal disease, which can be caused by diabetes, and is 50 percent more likely to die from diabetes than are non-Hispanic whites. Type 2 diabetes, in which the body doesn’t make enough insulin, affects more than 25 million Americans.
By carefully selecting individuals from large pedigrees and choosing to have those individuals whole genome sequenced by Complete Genomics, the diabetes study offers researchers the unique ability to use their pre-existing genome-wide association data to impute the whole genome sequencing results from 600 individuals into other family members. This will provide complete whole genotype information for more than 1,000 individuals, nearly doubling the set of whole genome sequenced individuals.
“We are delighted to work with the T2D-GENES researchers to develop new ways to maximize genomics’ potential to further medical knowledge,” said Dr. Clifford Reid, chairman, president and CEO of Complete Genomics. “We hope that their smart, elegant and cost-effective approach will lead to the development of targeted therapies for type 2 diabetes.”
T2D-GENES is an international consortium that involves investigators from more than 20 academic centers worldwide.
About Complete Genomics
Complete Genomics is the whole human genome sequencing company that has developed and commercialized an innovative DNA sequencing service. The Complete Genomics Analysis Platform (CGA™ Platform) combines Complete Genomics’ proprietary human genome sequencing technology with advanced informatics and data management software. Additional information can be found at http://www.completegenomics.com.
Certain statements in this press release, including with respect to the ability to identify certain genetic variants, are forward-looking statements that are subject to risks and uncertainties. These forward-looking statements are based on management's current expectations, and actual results may differ materially from our expectations. The following factors, without limitation, could cause actual results to differ materially from those in our forward-looking statements: the ability of researchers to identify diabetes-related genetic variants. More information on risk factors that could affect our results can be found in our Quarterly Report on Form 10-Q filed with the SEC on May 9, 2012, including those listed in that filing under the heading “Risk Factors.” We disclaim any obligation to update information contained in our forward-looking statements, whether as a result of new information, future events or otherwise.