Partner Magenta Therapeutics Exercises Option to Further Develop Antibody Targeted Amanitin Conjugates Targeted to CD45
Ladenburg, Germany, 11 November 2019 - Heidelberg Pharma AG (FSE: WL6) today announced that its partner Magenta Therapeutics (NASDAQ: MGTA), Cambridge, MA, USA, (Magenta) today declared that it will exercise the option for the exclusive worldwide development and marketing rights for Antibody Targeted Amanitin Conjugates (ATACs) targeting CD45. Heidelberg Pharma receives an undisclosed milestone payment in return. Under Heidelberg Pharma's collaboration with Magenta, Heidelberg Pharma is entitled to receive development and sales-related milestone payments of USD 85m per selected target. Pending successful completion of the research phase, Magenta may begin developing ATACs that target CD45.
In March 2018, both companies signed an exclusive multi-target research agreement under which Magenta gained access to Heidelberg Pharma's Amanitin toxin-linker platform technology. Magenta may apply Heidelberg Pharma's proprietary ATAC technology to up to four exclusive targets from its antibody portfolio to produce novel ATACs. Magenta exercised its first option for the CD117 target in October 2018.
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Information and Explanation of the Issuer to this News:
About the target molecule
The target CD45 is a surface protein expressed by immune cells and hematopoietic stem cells. An ATAC for CD45 could provide a one-time curative therapy for patients with autoimmune diseases by removing the disease-causing cells, resetting the immune system and allowing the body to rebuild a healthy new immune system.
About Heidelberg Pharma
Heidelberg Pharma is an oncology specialist and the first company to develop the toxin Amanitin into cancer therapies using its proprietary Antibody Targeted Amanitin Conjugate (ATAC) technology and to advance the biological mode of action of the toxin as a novel therapeutic principle. This proprietary technology platform is being applied to develop the Company's proprietary therapeutic ATACs as well as in third-party collaborations to create a variety of ATAC candidates. The proprietary lead candidate HDP-101 is a BCMA ATAC for multiple myeloma.
Former clinical assets MESUPRON(R) and REDECTANE(R) were partnered for further development and commercialization. Heidelberg Pharma AG is listed on the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol WL6. More information is available at www.heidelberg-pharma.com.
About Magenta Therapeutics
Headquartered in Cambridge, MA, USA, Magenta Therapeutics is a clinical-stage biotechnology company developing novel medicines for patients with autoimmune diseases, blood cancers and genetic diseases. By creating a platform focused on critical areas of unmet need, Magenta Therapeutics is pioneering an integrated approach to allow more patients to receive one-time, curative therapies by making the process more effective, safer and easier.
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