New Cardiac Arrhythmia Syndrome Identified

An international team led by researchers from Duke University Medical Center and the Howard Hughes Medical Institute (HHMI) have defined a previously undescribed inherited cardiac arrhythmia syndrome that can lead to sudden death and can strike young, seemingly healthy people. After discovering in 2003 a mutation in a specific gene in an extended French family for the arrhythmia, the researchers have identified four other similar mutations in different families worldwide, adding further evidence that they have indeed identified a new cardiac arrhythmia syndrome. The gene in question -- ankyrin-B -- encodes a protein that coordinates ion channels and transporters and thus regulates the flow of ions in and out of heart muscle cells, which in turn controls the beating of the heart.

Back to news