Cathepsin G is a neutrophil serine protease, stored in cytoplasmic granules and secreted into the extra- and pericellular space upon neutrophil activation.1 Cathepsin G plays important role in bacterial defense. It acts in combination with reactive oxygen species to help degrade engulfed microorganisms inside phagolysosomes.2,3 Besides bactericidal effect, Cathepsin G regulates the inflammatory response by specifically altering the function of cytokines and chemokines.4 Because of its role in host defense, Cathepsin G is of interest as a potential therapeutic target.5 http://www.anaspec.com/products/promotions.asp?col=1&row=1
References
1. Egesten, A. et al. Blood 83, 2985 (1994).
2. Korkmaz, B. et al. Biochimie. 90, 227 (2008).
3. Sienczyk M. et al. Bioorg Med Chem. 19,8863 (2008).
4. Pham, CT. Nat Rev Immunol. 6, 541 (2006).
5. Korkmaz, B. et al. Pharmacol Rev. 62, 726 (2010).
6. Lesner, A. et al. Anal Biochem. 375, 306 (2008).
7. Greco, MN. et al. J Am Chem Soc. 124, 3810 (2002).
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