Syrris, a world leader in flow product innovation, has been a driving force in enhancing R&D chemistry productivity ever since the company’s foundation 14 years ago. This achievement is amply recognised by the wealth of impressive publications describing novel flow chemistry applications developed using Syrris reactors.
Today, scientists have access to hundreds of flow chemistry papers citing groundbreaking applications established on modular reactors from Syrris, including the Ley group’s Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry1. The group, based at the University of Cambridge, took advantage of the Asia reactor’s continuous analysis and work-up capabilities to synthesise the natural products Spirodienal A and Spirangien A. This pioneering process, using solids, liquids and gases, combines 16 stages of a 21-step synthesis into one flow chemistry sequence, demonstrating just how far flow techniques have advanced.
The pharmaceutical industry is also benefitting from continuous flow techniques, as well as microfluidic electrosynthesis, with publications including A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir 2 and Preparative Microfluidic Electrosynthesis of Drug Metabolites3. Scientists worldwide can learn more about these and many other varied applications taking advantage of Syrris flow reactors – ranging from the early days of flow chemistry synthesis through to numerous present-day examples – by exploring the convenient reference guide at http://syrris.com/news/syrris-in-publications
1. Sean Newton, Catherine F. Carter, Colin M. Pearson, Leandro de C. Alves, Heiko Lange, Praew Thansandote, and Steven V. Ley (2014). Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry. Angew. Chem. Int. Ed. 53, 1-7.
2. Luciana Dalla-Vechia, Benedikt Reichart, Toma Glasnov, Leandro S. M. Miranda, C. Oliver Kappe and Rodrigo O. M. A. de Souza (2013). A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir. Org. Biomol. Chem. 11, 6806-6813.
3. Romain Stalder and Gregory P. Roth (2013). Preparative Microfluidic Electrosynthesis of Drug Metabolites. ACS Med. Chem. Lett. 4 (11), 1119–1123.
Syrris Limited
Syrris is world renowned for excellence in chemical reactor systems and is a world leader in flow chemistry systems. Established in 2001, Syrris employs over 30 scientists and engineers at its facility in Royston (near Cambridge, UK) and has offices in the US, Japan, India and Brazil plus over 30 distributors worldwide.
Syrris develops laboratory automation products for research and development chemists in industries such as pharma, petrochem, agrochem, fine chemical synthesis etc. as well as academia. Syrris products are used in a wide variety of applications and laboratories including process, discovery, crystallization, process safety, scale-up and many more.
Syrris products include the innovative range of fully automated batch reactor products (Atlas), a manually operated jacketed reactor platform (Globe) and flow chemistry systems (Asia and Africa). In recognition of its technological achievements, Syrris has been awarded the “Eastern Region’s UKTI Best Established Exporter” and the “Most Outstanding Export Achievement” at the Global Opportunity Conference on International Trade. Syrris’ Asia Flow Chemistry system was the recipient of a prestigious 2012 R&D award.
Today, scientists have access to hundreds of flow chemistry papers citing groundbreaking applications established on modular reactors from Syrris, including the Ley group’s Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry1. The group, based at the University of Cambridge, took advantage of the Asia reactor’s continuous analysis and work-up capabilities to synthesise the natural products Spirodienal A and Spirangien A. This pioneering process, using solids, liquids and gases, combines 16 stages of a 21-step synthesis into one flow chemistry sequence, demonstrating just how far flow techniques have advanced.
The pharmaceutical industry is also benefitting from continuous flow techniques, as well as microfluidic electrosynthesis, with publications including A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir 2 and Preparative Microfluidic Electrosynthesis of Drug Metabolites3. Scientists worldwide can learn more about these and many other varied applications taking advantage of Syrris flow reactors – ranging from the early days of flow chemistry synthesis through to numerous present-day examples – by exploring the convenient reference guide at http://syrris.com/news/syrris-in-publications
1. Sean Newton, Catherine F. Carter, Colin M. Pearson, Leandro de C. Alves, Heiko Lange, Praew Thansandote, and Steven V. Ley (2014). Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry. Angew. Chem. Int. Ed. 53, 1-7.
2. Luciana Dalla-Vechia, Benedikt Reichart, Toma Glasnov, Leandro S. M. Miranda, C. Oliver Kappe and Rodrigo O. M. A. de Souza (2013). A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir. Org. Biomol. Chem. 11, 6806-6813.
3. Romain Stalder and Gregory P. Roth (2013). Preparative Microfluidic Electrosynthesis of Drug Metabolites. ACS Med. Chem. Lett. 4 (11), 1119–1123.
Syrris Limited
Syrris is world renowned for excellence in chemical reactor systems and is a world leader in flow chemistry systems. Established in 2001, Syrris employs over 30 scientists and engineers at its facility in Royston (near Cambridge, UK) and has offices in the US, Japan, India and Brazil plus over 30 distributors worldwide.
Syrris develops laboratory automation products for research and development chemists in industries such as pharma, petrochem, agrochem, fine chemical synthesis etc. as well as academia. Syrris products are used in a wide variety of applications and laboratories including process, discovery, crystallization, process safety, scale-up and many more.
Syrris products include the innovative range of fully automated batch reactor products (Atlas), a manually operated jacketed reactor platform (Globe) and flow chemistry systems (Asia and Africa). In recognition of its technological achievements, Syrris has been awarded the “Eastern Region’s UKTI Best Established Exporter” and the “Most Outstanding Export Achievement” at the Global Opportunity Conference on International Trade. Syrris’ Asia Flow Chemistry system was the recipient of a prestigious 2012 R&D award.
