Totally Contained - Completely Flexible – Pharmaceutical Granulation by GEA Pharma Systems

April, 2011 -- GEA Pharma Systems will exhibit its premier contained pilot granulation system at Interpack, Düsseldorf in May2011. It is a complete production plant that takes the process from dispensed raw materials to finished tablet. The system on show clearly demonstrates the flexibility that can be achieved throughout the process – including high shear granulation, pelletization and blending, etc. – in a totally contained environment. It illustrates how GEA Pharma Systems’ inspired technology can be selected to form a total solution tailored to suit each user’s specific requirements, whether through integration or split valve technology.

The system is aimed at producers of small quantities of highly potent compounds. The intelligent contained handling systems inherent in the GEA pilot plant allow it to be flexible, efficient, clean and safe without the need for expensive, bulky and difficult to clean isolator systems. Furthermore the level of containment avoids the need for costly and uncomfortable airsuits, allowing the users to focus on the product, creating faster and more secure results.

Process Overview

At the heart of the production plant are PharmaConnect®, and Flexstream™. PharmaConnect® is GEA’s innovative, modular granulation and blending system offering an unbeatable range of process types and capacities; FlexStream™ is the world leading process technology for spray granulation and pellet coating, delivering unbeatable benefits in terms of greater productivity, lower running costs and a robust and scaleable process.

Contained product transfer

The system includes examples of both rigid and disposable product transfer technology offering containment down to low nanogram levels. These options include: the disposable Hicoflex® system with significantly lower capital and running costs compared with rigid IBC technology and rapid product changeover for improved plant utilization; the unique, modular Buck® MC valve with its simple design that enables complete container-to-container transfer flexibility; and the Buck® TC Valve, the highest performing split valve available in the market place. By introducing a wash step prior to valve separation, the Buck® TC Valve is capable of performance to the low nanogram level.

Integrated Approach

All of these technologies are brought together for Interpack, in an integrated process system that mimics the hundreds of large-scale plants provided by GEA Pharma Systems globally. It epitomises the approach of ensuring customers receive the same technology from the laboratory through to production, using the same containment and process technologies to ensure seamless scale-up and the most flexible blend of process capabilities.

Visit GEA Pharma Systems on stand number F24, Hall 8a and see the complete production plant in operation.

Experienced GEA engineers and sales staff will be on hand to answer questions.

Learn more about containment at Interpack 2011 www.gea-ps.com/interpack

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