WATERTOWN, Mass.--(BUSINESS WIRE)--Syros Pharmaceuticals, a therapeutics company focused on discovering and developing novel gene control therapies, announced today that data demonstrating the use of Syros’ gene control platform to identify biomarkers that predict drug response were presented at a recent meeting of cancer researchers. Research conducted by Syros scientists demonstrates a new approach to uncovering novel biomarkers that predict drug response.
In a poster presented on February 7 at the American Association for Cancer Research (AACR) Translation of the Cancer Genome meeting, entitled “Predicting Drug Response by Profiling the Epigenome Super-Enhancers as Biomarkers,”1 Syros scientists mapped gene control regions across 40 diverse cancer cell-lines and paired those maps against drug response data from 140 different anti-cancer drugs. Researchers were able to demonstrate that unique gene control elements could be used as biomarkers to predict response to drugs. This work suggests that interrogating gene control features can enable rational patient selection and therapeutic treatment strategies.
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