LEXINGTON, Mass.--(BUSINESS WIRE)--Synta Pharmaceuticals Corp. (NASDAQ: SNTA) presented preclinical results today at the 3rd European Lung Cancer Conference in Geneva, Switzerland that show ganetespib, a potent inhibitor of heat shock protein 90 (Hsp90), equally inhibits growth of both crizotinib-sensitive and -resistant cancer cells driven by the EML4-ALK fusion protein regardless of ALK mutation status. Additional results from mouse ALK+ NSCLC xenograft models demonstrated anticancer activity with combined administration of ganetespib and crizotinib that was significantly higher than when either drug was administered alone.
