Skyepharma PLC’s Chief Operating Officer Appointed To Board

LONDON, May 17 /PRNewswire-FirstCall/ -- SkyePharma PLC announces the appointment of Dr Ken Cunningham, Chief Operating Officer, as a Director of the Company. It was announced in February that Dr Ken Cunningham, previously Chief Executive of the privately-owned UK biotechnology company Arakis, would become Chief Operating Officer of SkyePharma and he took up this appointment on 24 April.

Dr Ken Cunningham said: “I am very pleased to join the Board of SkyePharma. With the ongoing divestment of our Injectables business, I will be focusing on the management of our core Oral and Inhalation products where I will apply my experience in pharmaceutical development. I am impressed by SkyePharma’s technical staff and see working with them to maximise the value of our pipeline products as a key part of my role at SkyePharma.”

Dr Jerry Karabelas, SkyePharma’s Non-executive Chairman, said: “We welcome Ken to the Board and look forward to gaining his input on operational and strategic decisions.”

Shareholders will have the opportunity to confirm the appointment of Dr Cunningham as a Director at the next Annual General Meeting, which will be in June 2006.

For further information please contact: SkyePharma PLC Frank Condella, Chief Executive +44 207 491 1777 Peter Laing, Director of Corporate Communications +44 207 491 5124 Sandra Haughton, US Investor Relations +1 212 753 5780 Buchanan Communications +44 207 466 5000 Tim Anderson / Mark Court / Rebecca Skye Dietrich About SkyePharma

SkyePharma PLC develops pharmaceutical products benefiting from world-leading drug delivery technologies that provide easier-to-use and more effective drug formulations. There are now twelve approved products incorporating SkyePharma’s technologies in the areas of oral, injectable, inhaled and topical delivery, supported by advanced solubilisation capabilities. For more information, visit http://www.skyepharma.com.

Certain statements in this news release are forward-looking statements and are made in reliance on the safe harbour provisions of the U.S. Private Securities Litigation Act of 1995. Although SkyePharma believes that the expectations reflected in these forward-looking statements are reasonable, it can give no assurance that these expectations will materialize. Because the expectations are subject to risks and uncertainties, actual results may vary significantly from those expressed or implied by the forward-looking statements based upon a number of factors, which are described in SkyePharma’s 20-F and other documents on file with the SEC. Factors that could cause differences between actual results and those implied by the forward-looking statements contained in this news release include, without limitation, risks related to the development of new products, risks related to obtaining and maintaining regulatory approval for existing, new or expanded indications of existing and new products, risks related to SkyePharma’s ability to manufacture products on a large scale or at all, risks related to SkyePharma’s and its marketing partners’ ability to market products on a large scale to maintain or expand market share in the face of changes in customer requirements, competition and technological change, risks related to regulatory compliance, the risk of product liability claims, risks related to the ownership and use of intellectual property, and risks related to SkyePharma’s ability to manage growth. SkyePharma undertakes no obligation to revise or update any such forward-looking statement to reflect events or circumstances after the date of this release.

SkyePharma PLC

CONTACT: Frank Condella, Chief Executive, +44-207-491-1777, or PeterLaing, Director of Corporate Communications, +44-207-491-5124, or SandraHaughton, US Investor Relations, +1-212-753-5780, all of SkyePharma PLC; orTim Anderson, or Mark Court, or Rebecca Skye Dietrich, all of BuchananCommunications, +44-207-466-5000

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