There’s been a surge in demand for complete NASH therapeutics in the past couple of years, which in turn has led to the projected launch of pipeline drugs.
There’s been a surge in demand for complete NASH therapeutics in the past couple of years, which in turn has led to the projected launch of pipeline drugs. At the same time, rise in the incidence of obesity and diabetes has been beneficial for the NASH market.
According to Allied Market Research, the global non-alcoholic steatohepatitis market is estimated to cite a considerable CAGR from 2021 to 2025. Rise in healthcare awareness in the developing nations such as China and India has fueled the market growth in more than one way.
Nonalcoholic fatty liver disease is now being considered as one of the prominent causes of death across the world, and has also come out as one of the most common health disorders globally. “Nonalcoholic steatohepatitis” (NASH), happens to take hold of about thirty percent of all patients suffering from NAFLD, and can give way to liver cancer as well as cirrhosis. Regardless of several research efforts, the primary reasons leading to NAFLD/NASH are still not clear, and thus it lacks an effective treatment.
Can FPR2 (protein formyl peptide receptor 2) be implied in the sex-related variances regarding NAFLD pervasiveness, frequency and severity?
Remitting this question, a research unit steered by one of the renowned professor of Pusan National University, Korea, namely Dr. Youngmi Jung showed a study utilizing mice model lately. The study seems to be flaking light on the role of FPR2 in Nonalcoholic steatohepatitis condition and its association with the observed sex-based differences. This is among the very few research works conducted on NAFLD that count on sex-balanced animal tests & trials rather than the usual male-only prototypes.
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The specialist researchers have come up with the conclusion that Fpr2 was highly found in livers of female mice that were healthy & fit enough. And interestingly, it was found in different proportion in the livers of female and mice that were suckled a special NAFLD-bred diet.
The researchers have also established the fact that FPR2 formation in the liver is arbitrated by estrogen. Males rounded off with peripheral estrogen formed more Fpr2 and were more resilient to NAFLD, while females, without ovaries, showcased concentrated liver Fpr2 levels. This unique discovery of the female-specific formation of FPR2 in the liver and its role in laying out defiance against non-alcoholic steatohepatitis will certainly pave the way for innovative treatments.