NEW YORK--(BUSINESS WIRE)--First-in-human results for IMC-A12, a monoclonal antibody developed by ImClone Systems Incorporated (NASDAQ: IMCL) and targeted to IGF-1R (insulin-like growth factor type 1 receptor), were presented at the annual meeting of the American Society of Clinical Oncology in Chicago. The IGF-IR is expressed on the cell surface of must human cancers and transmits signals that lead to tumor cell growth and proliferation, and inhibition of programmed cell death. Aberrant expression of the IGF-IR has been implicated in tumorigenesis and the development of tumor resistance to chemotherapy, hormonal therapies, and targeted therapies. IMC-A12 was well tolerated and showed activity in patients with advanced solid tumors.
