Nanobac Pharmaceuticals, Inc. Message to Shareholders

TAMPA, FL--(Marketwire - February 27, 2009) - Nanobac Pharmaceuticals Inc. (PINKSHEETS: NNBP) (“Nanobac” or “the Company”) announced that it is actively pursuing strategic alliances and potential merger opportunities. While the Board of Directors feels the underlying technology in the Company is sound, the constrained capital markets have limited the Company’s access to capital and therefore made it necessary to pursue new opportunities. It continues to be the Company’s goal to pursue all aspects of the original business plan, which included the characterization of Naobacteria or Calcifying Nanoparticles (CNPs). The Company anticipates moving very quickly toward an alliance or merger that will potentially create renewed shareholder value.

For more information on Nanobac Pharmaceuticals Inc. visit our website at: http://www.nanobac.com.

Investors are cautioned that certain statements in this document, some statements in periodic press releases and some oral statements of Nanobac Pharmaceuticals, Inc. officials are “Forward-Looking Statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (the “Act”). Forward-Looking statements include statements which are predictive in nature, which depend upon or refer to future events or conditions, which include words such as “believes,” “anticipates,” “intends,” “plans,” “expects,” and similar expressions. In addition, any statements concerning future financial performance (including future revenues, earnings or growth rates), ongoing business strategies or prospects, and possible future Nanobac Pharmaceuticals, Inc. actions, which may be provided by management, are also forward-looking statements as defined by the Act. Forward-Looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results, performance or achievements of the Company to materially differ from any future results, performance or achievements expressed or implied by such forward-looking statements and to vary significantly from reporting period to reporting period. Although management believes that the assumptions will, in fact, prove to be correct or that actual future results will not be different from the expectations expressed in this report. These statements are not guarantees of future performance and Nanobac Pharmaceuticals, Inc. has no specific intention to update these statements.