Melatonin, which is widely used as a sleep-aid, is also effective for migraine prevention, according to findings from a small trial. Melatonin is secreted by the pineal gland in the brain and is involved in regulating the circadian cycle. There is increasing evidence that melatonin secretion is related to headache disorders, Dr. Mario F. P. Peres, of Hospital Israelita Albert Einstein, in Sao Paulo, and colleagues note in the medical journal Neurology.
