People with medium levels of HIV in their blood are likely to contribute most to the spread of the virus, according to new research published today in the journal Proceedings of the National Academy of Sciences.The study, by researchers from Imperial College London, looked at several groups of HIV-positive people in Europe, the USA and sub-Saharan Africa. It found that those with a high viral load are the most infectious group, but have only limited time to infect others, because they generally progress to AIDS quite quickly.