Creative Biolabs has successfully developed GHA platform to germinalize humanized antibody production.
Creative Biolabs has successfully developed GHA® platform to germinalize humanized antibody production. While doing antibody related research and development, have you ever experienced the difficulty that the majority of the non-human residues in both CDR and FR regions are still immunogenic in humans no matter how hard you’ve tried? If so, you are sure to get rid of the agony in your next experiment. Creative Biolabs established the GHA® platform to germinalize humanized antibody production. Antibody humanization service followed by germinalization produces human antibodies with excellent germinality index (GI). Human antibodies optimized from this platform are almost equivalent to mature human antibodies in sequence and have minimal immunogenicity while retaining parental affinity and specificity.
Usually, engineered human antibodies with over 10% non-germline mutations often carry potential risks in generating more side effects. Creative Biolabs’ humanized antibody sequence germinalization strategies propose utmost amino acid substitutions to reduce immunogenicity while with the affinity remained.
Using in silico germinalization analyses, potential substitution residues on VL and VH (FR and CDR) will be identified and subsequently a mutant library with extensive germinalization will be constructed. Combined with our expertise in phage display library screening, the best lead candidates will be selected, purified and thoroughly characterized.
Antibodies derived from Monkeys and other NHP (Non-human primates) are of the most similarity in sequence to human antibodies. As a result, humanized NHP antibodies are the easiest ones to be further germinalized so as to have the highest germinality index (GI). For this reason, monoclonal antibodies raised in NHP (Non-human primates) potentially have the lowest risk when developed into therapeutics for human use. Creative Biolabs has great expertise in monoclonal NHP (Non-human Primates) antibody production, and it is particularly experienced in performing in-depth humanization for monoclonal antibodies raised in NHP (Non-human primates). Germinalization of humanized NHP antibodies can deliver human antibodies with about 95% homology to the human germinal antibody sequences.
About Creative Biolabs
Creative Biolabs is a professional biotech service provider located in New York. With years of experience in the field of antibody production and antibody services, Creative Biolabs are offering satisfying services for customers from all over the world.
Contact
Bella Smith Marketing Specialist
(631)619-7922
marketing@creative-biolabs.com
