Study In Mice Suggests Coconut Oil Can Control Overgrowth Of A Fungal Pathogen In GI Tract
BOSTON (Nov. 18, 2015; 11:00 a.m. EST)—A new inter-disciplinary study led by researchers at Tufts University found that coconut oil effectively controlled the overgrowth of a fungal pathogen called Candida albicans (C. albicans) in mice. In humans, high levels of C. albicans in the gastrointestinal tract can lead to bloodstream infections, including invasive candidiasis. The research, published in mSphere, suggests that it might be possible to use dietary approaches as an alternative to antifungal drugs in order to decrease the risk of infections caused by C. albicans.
C. albicans, a common fungal pathogen, is part of the gastrointestinal tract’s normal flora and well-regulated by the immune system. When the immune system is compromised, however, the fungus can spread beyond the GI tract and cause disease. Systemic infections caused by C. albicans can lead to invasive candidiasis, which is the fourth most common blood infection among hospitalized patients in the United States according to the CDC. The infection is most common among immunocompromised patients, including premature infants and older adults.
Antifungal drugs can be used to decrease and control C. albicans in the gut and prevent it from spreading to the bloodstream, but repeated use of antifungal drugs can lead to drug resistant-strains of fungal pathogens. In order to prevent infections caused by C. albicans, the amount of C. albicans in the gastrointestinal tract needs to be reduced.
The team, led by microbiologist Carol Kumamoto and nutrition scientist Alice H. Lichtenstein, investigated the effects of three different dietary fats on the amount of C. albicans in the mouse gut: coconut oil, beef tallow and soybean oil. A control group of mice were fed a standard diet for mice. Coconut oil was selected based on previous studies that found that the fat had antifungal properties in the laboratory setting.
A coconut oil-rich diet reduced C. albicans in the gut compared to a beef tallow-or soybean oil-rich diet. Coconut oil alone, or the combination of coconut oil and beef tallow, reduced the amount of C. albicans in the gut by more than 90% compared to a beef tallow-rich diet.
“Coconut oil even reduced fungal colonization when mice were switched from beef tallow to coconut oil, or when mice were fed both beef tallow and coconut oil at the same time. These findings suggest that adding coconut oil to a patient’s existing diet might control the growth of C. albicans in the gut, and possibly decrease the risk of fungal infections caused by C. albicans,” said Kumamoto, Ph.D., a professor of molecular biology and microbiology at Tufts University School of Medicine and member of the molecular microbiology and genetics program faculties at the Sackler School of Graduate Biomedical Sciences.
“Food can be a powerful ally in reducing the risk of disease,” said Alice H Lichtenstein, D.Sc., director of the Cardiovascular Nutrition Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. “This study marks a first step in understanding how life-threatening yeast infections in susceptible individuals might be reduced through the short-term and targeted use of a specific type of fat. As exciting as these findings are, we have to keep in mind that the majority of adult Americans are at high risk for heart disease, the number one killer in the U.S. The potential use of coconut oil in the short term to control the rate of fungal overgrowth should not be considered a prophylactic approach to preventing fungal infections.”
“We want to give clinicians a treatment option that might limit the need for antifungal drugs. If we can use coconut oil as a safe, dietary alternative, we could decrease the amount of antifungal drugs used, reserving antifungal drugs for critical situations,” said first author Kearney Gunsalus, Ph.D., an Institutional Research and Academic Career Development (IRACDA) postdoctoral fellow at the Sackler School in Kumamoto’s lab.
Kumamoto, Gunsalus and Dr. Joseph Bliss at Brown/Women & Infants Hospital have proposed a clinical trial to assess the efficacy of coconut oil to reduce the amount of C. albicans in the gut of premature infants who are at high risk.
Additional authors of this study are Stephanie Tornberg-Belanger, M.S., M.P.H, formerly a research technician in Kumamoto’s lab, and Nirupa R. Matthan, Ph.D., scientist in the Cardiovascular Nutrition Laboratory at USDA HNRCA.
Gunsalas was supported by Institutional Research Career and Academic Development Award Number K12GM074869 from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH). The Institutional Research Career and Academic Development Awards from the NIGMS combine traditional post-doctoral research work with mentored teaching experience at institutions that serve under-represented minorities. The Sackler School’s IRACDA Training in Education and Critical Research Skills (TEACRS) program is a partnership with the University of Massachusetts, Boston; Pine Manor College, and Bunker Hill Community College. It is the only IRACDA-funded program in New England.
Research reported in this publication was also supported by a pilot project grant to Kumamoto and Lichtenstein from Tufts Clinical and Translational Science Institute (CTSI) via the then-called National Center for Research Resources (award UL1RR025752), and an award by the National Institute of Allergy and Infectious Resources Disease to Kumamoto (award R01AI081794). Statistical support was provided by Tufts CTSI via the National Center for Advancing Translational Sciences of the NIH under award numbers UL1TR000073 and UL1TR001064.
Gunsalus, K.T.W., Tornberg-Belanger, S.N., Matthan, N.R.., Lichtenstein, A.H., Kumamoto, C.A. (Nov. 18, 2015). Manipulation of host diet to reduce gastrointestinal colonization by the opportunistic pathogen Candida albicans. mSphere. DOI: 10.1128/mSphere.00020-15
About Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences
Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University are international leaders in innovative medical and population health education and advanced research. Tufts University School of Medicine emphasizes rigorous fundamentals in a dynamic learning environment to educate physicians, scientists, and public health professionals to become leaders in their fields. The School of Medicine and the Sackler School are renowned for excellence in education in general medicine, the biomedical sciences, and public health, as well as for innovative research at the cellular, molecular, and population health level. Ranked among the top in the nation, the School of Medicine is affiliated with six major teaching hospitals and more than 30 health care facilities. Tufts University School of Medicine and the Sackler School undertake research that is consistently rated among the highest in the nation for its effect on the advancement of medical and prevention science.
About the Jean Mayer USDA Human Nutrition Research Center on Aging and the Friedman School of Nutrition Science and Policy
For three decades, the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University has studied the relationship between good nutrition and good health in aging populations. Tufts research scientists work with federal agencies to establish the USDA Dietary Guidelines, the Dietary Reference Intakes, and other significant public policies. The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University is the only independent school of nutrition in the United States. The school’s eight degree programs – which focus on questions relating to nutrition and chronic diseases, molecular nutrition, agriculture and sustainability, food security, humanitarian assistance, public health nutrition, and food policy and economics – are renowned for the application of scientific research to national and international policy.
