A genetically engineered mouse that is resistant to bowel cancer may help scientists develop new methods to prevent and treat one the most common cancers in the developed world. Professor Alan Clarke and a team of researchers at Cardiff University in Wales created the GM mouse by knocking out a gene called Mbd2 and breeding it with so-called “Min” mice which are highly susceptible to the disease. They found that the offspring that inherited the predisposition to cancer but did not have the gene lived twice as long as the other mice and had a ten-fold reduction in tumors.
