BioTie Therapies Corp. Release: Notification According to Chapter 2, Section 10 of the Finnish Securities Market Act

Biotie Therapies Corp. (“Biotie” or the “Company”) has on 10 December 2009 gained knowledge of the notification regarding the following change in holdings in accordance with Chapter 2, Section 9 of the Finnish Securities Markets Act.

Finnish Innovation Fund (Sitra) has notified the Company that as a result of a share transaction carried out on 7 December 2009, the holdings of Finnish Innovation Fund (Sitra) in the Company have decreased below 1/10 (i.e. 10 %), however, the holdings still exceed 1/20 (i.e. 5 %) of the total number of shares and votes in Biotie.

The change in holdings in accordance with Chapter 2, Section 9 of the Finnish Securities Markets Act is described below.

The registered number of shares in Biotie is 144,320,560 and the number of voting rights attached to the shares amounts to 143,857,305. After the 14,432,000 new shares issued in the share issue disclosed by the Company through stock exchange releases on 4 December 2009 and 7 December 2009 shall be registered with the Trade Register on or about 14 December 2009, the number of shares in the Company shall be 158,752,560 and the number of votes 158,289,305.

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