CAMBRIDGE, Mass.--(BUSINESS WIRE)--Dec. 19, 2005-- Pioneer in High-Speed, High-Sensitivity True Single Molecule Sequencing (tSMS(TM)) Conducts First Successful M13 Sequencing Using Non-Amplified Single Molecule-Based Technology. In a first-of-its-kind achievement in high-speed sequencing, Helicos BioSciences today announced that it has successfully sequenced the M13 genome, by utilizing its non-amplified True Single Molecule Sequencing (tSMS(TM)) technology in conjunction with its SimplePrep(TM) genome preparation technique. Sequencing of M13 was conducted on the entire genome, including so-called homopolymeric sequences.