Natera to Present New Colorectal Cancer Data at the 2021 ASCO GI Symposium
SAN CARLOS, Calif., Jan. 12, 2021 /PRNewswire/ -- Natera, Inc. (NASDAQ: NTRA), a pioneer and global leader in cell-free DNA testing, today announced it will present new data on its personalized and tumor-informed molecular residual disease (MRD) test, Signatera, at the American Society of Clinical Oncology's 2021 Gastrointestinal Cancers Symposium (ASCO GI), taking place January 15-17, 2021.
Natera will have one oral and one poster presentation, each describing the clinical performance of Signatera in patients with colorectal cancer (CRC).
Details about the presentations are as follows:
Abstract #11 | Oral Presentation | Presenter: Tenna V. Henriksen, MS | Jan. 16, 6:00 am PST
Circulating tumor DNA analysis for assessment of recurrence risk, benefit of adjuvant therapy, and early relapse detection after treatment in colorectal cancer patients
This multi-center study evaluates the prognostic value of longitudinal circulating tumor DNA (ctDNA) monitoring with Signatera in early-stage CRC. A cohort of 265 stage I-III CRC patients was followed for approximately three years (median of 28.4 months). Plasma samples were analyzed post-surgery, after adjuvant chemotherapy, and at regular intervals thereafter. The study demonstrates that Signatera detects recurrence early, with a median lead time of eight months before clinical or radiographic relapse; and compared to all other clinical and pathological risk factors, Signatera MRD status is the only significant risk factor in predicting recurrence.
"Our study is unique in that it is, to the best of our knowledge, the largest ctDNA study in early-stage CRC, with extremely mature follow-up," said Claus Lindbjerg Andersen, PhD, Professor, Department of Molecular Medicine at Aarhus University and the study's senior author. "Through this study, we are able to demonstrate that serial ctDNA testing can detect molecular residual disease a median of eight months ahead of clinical relapse, with significant potential to improve patient care."
Abstract #102 | Poster Presentation | Principal Investigator: David Cunningham, MD | Jan. 15, 5:00 am PST
Minimal residual disease (MRD) detection with circulating tumor DNA (ctDNA) from personalized assays in stage II-III colorectal cancer patients in a U.K. multicenter prospective study (TRACC)
A prospective study on 122 patients with stage II-III CRC, who were monitored pre- and post-surgery using Signatera. Patients who were MRD-positive after surgery had a significantly higher rate of relapse than those who were MRD-negative. MRD detection rates increase with disease stage and risk features, and correlate with recurrence rates.
"We are delighted to share the results of these studies with the ASCO GI community," said Alexey Aleshin, MD, Natera's Senior Medical Director of Oncology. "These data build on our previous studies, providing yet another consistent proof point for the clinical performance of Signatera in CRC and demonstrating our commitment towards research and innovation in the MRD field."
Investor Relations: Mike Brophy, CFO, Natera, Inc., 650-249-9090
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SOURCE Natera, Inc.
Company Codes: NASDAQ-NMS:NTRA