Catalyst Biosciences To Present At The Ladenburg Thalmann 2016 Healthcare Conference
Presentation will Focus on Preclinical Data and Development Strategy for Subcutaneous Prophylaxis of Individuals with Hemophilia
SOUTH SAN FRANCISCO, Calif., Sept. 23, 2016 (GLOBE NEWSWIRE) -- Catalyst Biosciences, Inc. (Nasdaq:CBIO), a clinical-stage biotechnology company focused on creating and developing novel protease therapeutics to treat serious medical conditions in the field of hemostasis, today announced that Nassim Usman, Ph.D., President and Chief Executive Officer, will present a corporate overview at the Ladenburg Thalmann 2016 Healthcare Conference, being held in New York City September 27, 2016.
Ladenburg Thalmann 2016 Healthcare Conference – Catalyst Biosciences Presentation Details
Date: Tuesday, September 27, 2016
Time: 3:00 p.m. Eastern Time
Location: Sofitel New York, New York City, St. Germain Room
About Hemophilia and Factor Replacement Therapy Hemophilia, for which there is no cure, is a rare but serious bleeding disorder that results from a genetic or an acquired deficiency of a protein required for normal blood coagulation. There are two major types of hemophilia, A and B, that are caused by alterations in Factor VIII or Factor IX genes, respectively, with a corresponding deficiency in the affected proteins. The prevalence of hemophilia A and B in the United States is estimated to be around 20,000 people, with more than 400,000 cases worldwide. Individuals with hemophilia suffer from spontaneous bleeding episodes as well as substantially prolonged bleeding times upon injury. In cases of severe hemophilia, spontaneous bleeding into muscles or joints is frequent and often results in permanent, disabling joint damage and can become life threatening. Treatment usually involves management of acute bleeding episodes or prophylaxis with factor replacement therapy by intravenous (IV) infusion of an individual’s missing Factor VIII or IX or, in the case of individuals who have developed inhibitors to their replacement factor, FVIIa. Adherence to a prophylaxis regimen is difficult because of the frequent IV infusion schedule of most currently approved therapies. In addition, convenient access to peripheral veins is often a problem, and many children require insertion of a central venous access device, with the concomitant risks of infection and thrombosis.
About Marzeptacog alfa (activated) Factor VIIa Marzeptacog alfa (formerly known as CB 813d) is a highly potent next-generation Factor VIIa that has successfully completed an IV Phase 1 clinical trial in individuals with severe hemophilia A and B both with and without inhibitors. Marzeptacog alfa (activated) was designed to combine higher clot-generating activity (high potency) at the site of bleeding and is being developed for the subcutaneous prophylaxis of individuals with severe hemophilia A and B with inhibitors.
About Factor IX
CB 2679d/ISU304 is a next-generation high potency coagulation Factor IX variant that is in advanced preclinical development. CB 2679d has exhibited enhanced procoagulant activity, improved efficacy in reducing blood loss, and prolonged duration of action in bleeding and non-bleeding preclinical models compared with other Factor IX products on the market and in development. Based on these findings, Catalyst believes that CB 2679d may allow for subcutaneous dosing in individuals with hemophilia B. Catalyst is developing CB 2679d in collaboration with ISU Abxis (KOSDAQ:086890) through a Phase 1/2 proof-of-concept subcutaneous administration study in individuals with hemophilia B. Following completion of the Phase 1/2 study, ISU Abxis has an option for exclusive commercial rights in South Korea while Catalyst retains full development and commercial rights for CB 2679d outside of South Korea.
About Catalyst
Catalyst is a clinical-stage biopharmaceutical company focused on developing novel medicines to address hematology indications. Catalyst is focused on the field of hemostasis, including the subcutaneous prophylaxis of hemophilia and facilitating surgery in individuals with hemophilia. Catalyst’s most advanced program is an improved next-generation coagulation Factor VIIa variant, marzeptacog alfa (activated), that has successfully completed an intravenous Phase 1 clinical trial in individuals with severe hemophilia A and B. Catalyst is also developing a next-generation Factor IX variant, CB 2679d/ISU304, that is in advanced preclinical development. For more information, please visit www.catalystbiosciences.com
SOUTH SAN FRANCISCO, Calif., Sept. 23, 2016 (GLOBE NEWSWIRE) -- Catalyst Biosciences, Inc. (Nasdaq:CBIO), a clinical-stage biotechnology company focused on creating and developing novel protease therapeutics to treat serious medical conditions in the field of hemostasis, today announced that Nassim Usman, Ph.D., President and Chief Executive Officer, will present a corporate overview at the Ladenburg Thalmann 2016 Healthcare Conference, being held in New York City September 27, 2016.
Ladenburg Thalmann 2016 Healthcare Conference – Catalyst Biosciences Presentation Details
Date: Tuesday, September 27, 2016
Time: 3:00 p.m. Eastern Time
Location: Sofitel New York, New York City, St. Germain Room
About Hemophilia and Factor Replacement Therapy Hemophilia, for which there is no cure, is a rare but serious bleeding disorder that results from a genetic or an acquired deficiency of a protein required for normal blood coagulation. There are two major types of hemophilia, A and B, that are caused by alterations in Factor VIII or Factor IX genes, respectively, with a corresponding deficiency in the affected proteins. The prevalence of hemophilia A and B in the United States is estimated to be around 20,000 people, with more than 400,000 cases worldwide. Individuals with hemophilia suffer from spontaneous bleeding episodes as well as substantially prolonged bleeding times upon injury. In cases of severe hemophilia, spontaneous bleeding into muscles or joints is frequent and often results in permanent, disabling joint damage and can become life threatening. Treatment usually involves management of acute bleeding episodes or prophylaxis with factor replacement therapy by intravenous (IV) infusion of an individual’s missing Factor VIII or IX or, in the case of individuals who have developed inhibitors to their replacement factor, FVIIa. Adherence to a prophylaxis regimen is difficult because of the frequent IV infusion schedule of most currently approved therapies. In addition, convenient access to peripheral veins is often a problem, and many children require insertion of a central venous access device, with the concomitant risks of infection and thrombosis.
About Marzeptacog alfa (activated) Factor VIIa Marzeptacog alfa (formerly known as CB 813d) is a highly potent next-generation Factor VIIa that has successfully completed an IV Phase 1 clinical trial in individuals with severe hemophilia A and B both with and without inhibitors. Marzeptacog alfa (activated) was designed to combine higher clot-generating activity (high potency) at the site of bleeding and is being developed for the subcutaneous prophylaxis of individuals with severe hemophilia A and B with inhibitors.
About Factor IX
CB 2679d/ISU304 is a next-generation high potency coagulation Factor IX variant that is in advanced preclinical development. CB 2679d has exhibited enhanced procoagulant activity, improved efficacy in reducing blood loss, and prolonged duration of action in bleeding and non-bleeding preclinical models compared with other Factor IX products on the market and in development. Based on these findings, Catalyst believes that CB 2679d may allow for subcutaneous dosing in individuals with hemophilia B. Catalyst is developing CB 2679d in collaboration with ISU Abxis (KOSDAQ:086890) through a Phase 1/2 proof-of-concept subcutaneous administration study in individuals with hemophilia B. Following completion of the Phase 1/2 study, ISU Abxis has an option for exclusive commercial rights in South Korea while Catalyst retains full development and commercial rights for CB 2679d outside of South Korea.
About Catalyst
Catalyst is a clinical-stage biopharmaceutical company focused on developing novel medicines to address hematology indications. Catalyst is focused on the field of hemostasis, including the subcutaneous prophylaxis of hemophilia and facilitating surgery in individuals with hemophilia. Catalyst’s most advanced program is an improved next-generation coagulation Factor VIIa variant, marzeptacog alfa (activated), that has successfully completed an intravenous Phase 1 clinical trial in individuals with severe hemophilia A and B. Catalyst is also developing a next-generation Factor IX variant, CB 2679d/ISU304, that is in advanced preclinical development. For more information, please visit www.catalystbiosciences.com