Alivio Technology for Treating Inflammatory Diseases via Targeted Disease Immunomodulation Published in Nature Communications
Published: Apr 03, 2018
Alivio Therapeutics, an affiliate of PureTech Health (PRTC.L), is pioneering targeted disease immunomodulation as a novel strategy to treat a range of chronic and acute inflammatory disorders. Targeted disease immunomodulation involves tuning the immune system exclusively at the site of disease in the body, with minimal impact on the rest of the immune system. This long sought-after approach has potential to treat a range of chronic and acute inflammatory disorders including ones that would otherwise be difficult to treat. Alivio’s proprietary Inflammation-Targeted Technology, based on the research of Dr. Karp and Dr. Robert Langer, David H. Koch Institute Professor at MIT, is the first technology to reproducibly show the ability to target immunomodulatory compounds to inflamed tissue, which can lead to dramatic improvements in treatment efficacy with major reductions in systemic effects. The platform has been validated in multiple labs and in eight different animal models of inflammation where the inflammation occurred in different parts of the body (e.g., the GI system, the bladder, joints, skin, etc.). The technology could potentially be used with a variety of medications (e.g., small molecules, peptides, proteins and nucleic acids) to address the dozens of conditions where inflammation is a central part of the underlying disease pathology, but where targeted and effective treatment options are lacking.
Alivio is developing its proprietary technology in collaboration with several of the world’s leading experts in biomaterials and immunology. Expert advisors include: Jeff Karp, PhD, Professor of Medicine at Brigham & Women’s Hospital and Alivio co-founder; Robert Langer, ScD, Co-Alivio Founder and Non-Executive Director at PureTech Health and David H. Koch Institute Professor at MIT; Michael B. Brenner, MD, Chief of the Division of Rheumatology, Immunology and Allergy at BWH; Ulrich H. von Andrian, MD, PhD, Mallinckrodt Professor of Immunopathology at Harvard Medical School; and Ralph Weissleder, MD, PhD, Director of the Center for Systems Biology at Massachusetts General Hospital.
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Source: Alivio Therapeutics